diff --git a/CHANGELOG.md b/CHANGELOG.md
index d091e4915..e1f4977dc 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -1,5 +1,11 @@
 # Changelog
 
+## Unreleased
+
+### Features
+
+- Allow tracing instrumentation and runtime optimizations to be disabled for specific variants, build types, or flavors without disabling other Sentry plugin features ([#1409](https://github.com/getsentry/sentry-android-gradle-plugin/pull/1409))
+
 ## 6.19.0
 
 ### Fixes
diff --git a/plugin-build/src/main/kotlin/io/sentry/android/gradle/AndroidComponentsConfig.kt b/plugin-build/src/main/kotlin/io/sentry/android/gradle/AndroidComponentsConfig.kt
index ad44625a6..a67c118fe 100644
--- a/plugin-build/src/main/kotlin/io/sentry/android/gradle/AndroidComponentsConfig.kt
+++ b/plugin-build/src/main/kotlin/io/sentry/android/gradle/AndroidComponentsConfig.kt
@@ -179,8 +179,22 @@ fun ApplicationAndroidComponentsExtension.configure(
         }
       }
 
-      val runtimeOptimizationsEnabled = extension.runtimeOptimizations.enabled.get()
-      val tracingInstrumentationEnabled = extension.tracingInstrumentation.enabled.get()
+      val runtimeOptimizations = extension.runtimeOptimizations
+      val runtimeOptimizationsEnabled =
+        variant.isInstrumentationEnabled(
+          runtimeOptimizations.enabled.get(),
+          runtimeOptimizations.ignoredVariants,
+          runtimeOptimizations.ignoredBuildTypes,
+          runtimeOptimizations.ignoredFlavors,
+        )
+      val tracingInstrumentation = extension.tracingInstrumentation
+      val tracingInstrumentationEnabled =
+        variant.isInstrumentationEnabled(
+          tracingInstrumentation.enabled.get(),
+          tracingInstrumentation.ignoredVariants,
+          tracingInstrumentation.ignoredBuildTypes,
+          tracingInstrumentation.ignoredFlavors,
+        )
       // Both visitor factories need the resolved dependency graph.
       val modulesService =
         if (runtimeOptimizationsEnabled || tracingInstrumentationEnabled) {
@@ -581,6 +595,17 @@ fun Variant.configureUploadAppTasks(
   return uploadBundleTask to uploadApkTask
 }
 
+private fun Variant.isInstrumentationEnabled(
+  enabled: Boolean,
+  ignoredVariants: SetProperty<String>,
+  ignoredBuildTypes: SetProperty<String>,
+  ignoredFlavors: SetProperty<String>,
+): Boolean =
+  enabled &&
+    name !in ignoredVariants.get() &&
+    flavorName !in ignoredFlavors.get() &&
+    buildType !in ignoredBuildTypes.get()
+
 private fun <T : InstrumentationParameters> Variant.configureInstrumentation(
   classVisitorFactoryImplClass: Class<out AsmClassVisitorFactory<T>>,
   scope: InstrumentationScope,
diff --git a/plugin-build/src/main/kotlin/io/sentry/android/gradle/extensions/RuntimeOptimizationsExtension.kt b/plugin-build/src/main/kotlin/io/sentry/android/gradle/extensions/RuntimeOptimizationsExtension.kt
index e22fef4f3..b6b15126c 100644
--- a/plugin-build/src/main/kotlin/io/sentry/android/gradle/extensions/RuntimeOptimizationsExtension.kt
+++ b/plugin-build/src/main/kotlin/io/sentry/android/gradle/extensions/RuntimeOptimizationsExtension.kt
@@ -3,10 +3,23 @@ package io.sentry.android.gradle.extensions
 import javax.inject.Inject
 import org.gradle.api.model.ObjectFactory
 import org.gradle.api.provider.Property
+import org.gradle.api.provider.SetProperty
 
 open class RuntimeOptimizationsExtension @Inject constructor(objects: ObjectFactory) {
   /**
    * Enables runtime optimizations of the Sentry SDK at the cost of build time. Defaults to true.
    */
   val enabled: Property<Boolean> = objects.property(Boolean::class.java).convention(true)
+
+  /** Android build variants for which runtime optimizations should be disabled. */
+  val ignoredVariants: SetProperty<String> =
+    objects.setProperty(String::class.java).convention(emptySet())
+
+  /** Android build types for which runtime optimizations should be disabled. */
+  val ignoredBuildTypes: SetProperty<String> =
+    objects.setProperty(String::class.java).convention(emptySet())
+
+  /** Android build flavors for which runtime optimizations should be disabled. */
+  val ignoredFlavors: SetProperty<String> =
+    objects.setProperty(String::class.java).convention(emptySet())
 }
diff --git a/plugin-build/src/main/kotlin/io/sentry/android/gradle/extensions/TracingInstrumentationExtension.kt b/plugin-build/src/main/kotlin/io/sentry/android/gradle/extensions/TracingInstrumentationExtension.kt
index f23176c34..2918b1a0b 100644
--- a/plugin-build/src/main/kotlin/io/sentry/android/gradle/extensions/TracingInstrumentationExtension.kt
+++ b/plugin-build/src/main/kotlin/io/sentry/android/gradle/extensions/TracingInstrumentationExtension.kt
@@ -13,6 +13,18 @@ open class TracingInstrumentationExtension @Inject constructor(objects: ObjectFa
    */
   val enabled: Property<Boolean> = objects.property(Boolean::class.java).convention(true)
 
+  /** Android build variants for which tracing instrumentation should be disabled. */
+  val ignoredVariants: SetProperty<String> =
+    objects.setProperty(String::class.java).convention(emptySet())
+
+  /** Android build types for which tracing instrumentation should be disabled. */
+  val ignoredBuildTypes: SetProperty<String> =
+    objects.setProperty(String::class.java).convention(emptySet())
+
+  /** Android build flavors for which tracing instrumentation should be disabled. */
+  val ignoredFlavors: SetProperty<String> =
+    objects.setProperty(String::class.java).convention(emptySet())
+
   /**
    * Enabled debug output of the plugin. Useful when there are issues with code instrumentation,
    * shows the modified bytecode. Defaults to false.
diff --git a/plugin-build/src/test/kotlin/io/sentry/android/gradle/integration/SentryPluginVariantTest.kt b/plugin-build/src/test/kotlin/io/sentry/android/gradle/integration/SentryPluginVariantTest.kt
index 866f2a4e5..69e3baa92 100644
--- a/plugin-build/src/test/kotlin/io/sentry/android/gradle/integration/SentryPluginVariantTest.kt
+++ b/plugin-build/src/test/kotlin/io/sentry/android/gradle/integration/SentryPluginVariantTest.kt
@@ -1,5 +1,6 @@
 package io.sentry.android.gradle.integration
 
+import com.google.common.truth.Truth.assertThat
 import io.sentry.BuildConfig
 import org.gradle.util.GradleVersion
 import org.junit.Assert.assertFalse
@@ -83,6 +84,107 @@ class SentryPluginVariantTest :
     assertTrue(":app:uploadSentryProguardMappingsDemoRelease" in build.output)
   }
 
+  @Test
+  fun `skips tracing for ignored variant while preserving mapping upload`() {
+    applyTracingIgnores(ignoredVariants = setOf("fullRelease"))
+
+    val ignoredBuild = runner.appendArguments(":app:assembleFullRelease", "--dry-run").build()
+
+    assertThat(ignoredBuild.output).doesNotContain(":app:transformFullReleaseClassesWithAsm")
+    assertThat(ignoredBuild.output).contains(":app:uploadSentryProguardMappingsFullRelease")
+
+    val allowedBuild = runner.appendArguments(":app:assembleDemoRelease", "--dry-run").build()
+
+    assertThat(allowedBuild.output).contains(":app:transformDemoReleaseClassesWithAsm")
+  }
+
+  @Test
+  fun `skips tracing for ignored build type while preserving mapping upload`() {
+    applyTracingIgnores(ignoredBuildTypes = setOf("release"))
+
+    val ignoredBuild = runner.appendArguments(":app:assembleFullRelease", "--dry-run").build()
+
+    assertThat(ignoredBuild.output).doesNotContain(":app:transformFullReleaseClassesWithAsm")
+    assertThat(ignoredBuild.output).contains(":app:uploadSentryProguardMappingsFullRelease")
+
+    val allowedBuild = runner.appendArguments(":app:assembleFullDebug", "--dry-run").build()
+
+    assertThat(allowedBuild.output).contains(":app:transformFullDebugClassesWithAsm")
+  }
+
+  @Test
+  fun `skips tracing for ignored flavor while preserving mapping upload`() {
+    applyTracingIgnores(ignoredFlavors = setOf("full"))
+
+    val ignoredBuild = runner.appendArguments(":app:assembleFullRelease", "--dry-run").build()
+
+    assertThat(ignoredBuild.output).doesNotContain(":app:transformFullReleaseClassesWithAsm")
+    assertThat(ignoredBuild.output).contains(":app:uploadSentryProguardMappingsFullRelease")
+
+    val allowedBuild = runner.appendArguments(":app:assembleDemoRelease", "--dry-run").build()
+
+    assertThat(allowedBuild.output).contains(":app:transformDemoReleaseClassesWithAsm")
+  }
+
+  @Test
+  fun `skips runtime optimizations for ignored variant while preserving mapping upload`() {
+    applyRuntimeOptimizationIgnores(ignoredVariants = setOf("fullRelease"))
+
+    val ignoredBuild = runner.appendArguments(":app:assembleFullRelease", "--dry-run").build()
+
+    assertThat(ignoredBuild.output).doesNotContain(":app:transformFullReleaseClassesWithAsm")
+    assertThat(ignoredBuild.output).contains(":app:uploadSentryProguardMappingsFullRelease")
+
+    val allowedBuild = runner.appendArguments(":app:assembleDemoRelease", "--dry-run").build()
+
+    assertThat(allowedBuild.output).contains(":app:transformDemoReleaseClassesWithAsm")
+  }
+
+  @Test
+  fun `skips runtime optimizations for ignored build type while preserving mapping upload`() {
+    applyRuntimeOptimizationIgnores(ignoredBuildTypes = setOf("release"))
+
+    val ignoredBuild = runner.appendArguments(":app:assembleFullRelease", "--dry-run").build()
+
+    assertThat(ignoredBuild.output).doesNotContain(":app:transformFullReleaseClassesWithAsm")
+    assertThat(ignoredBuild.output).contains(":app:uploadSentryProguardMappingsFullRelease")
+
+    val allowedBuild = runner.appendArguments(":app:assembleFullDebug", "--dry-run").build()
+
+    assertThat(allowedBuild.output).contains(":app:transformFullDebugClassesWithAsm")
+  }
+
+  @Test
+  fun `skips runtime optimizations for ignored flavor while preserving mapping upload`() {
+    applyRuntimeOptimizationIgnores(ignoredFlavors = setOf("full"))
+
+    val ignoredBuild = runner.appendArguments(":app:assembleFullRelease", "--dry-run").build()
+
+    assertThat(ignoredBuild.output).doesNotContain(":app:transformFullReleaseClassesWithAsm")
+    assertThat(ignoredBuild.output).contains(":app:uploadSentryProguardMappingsFullRelease")
+
+    val allowedBuild = runner.appendArguments(":app:assembleDemoRelease", "--dry-run").build()
+
+    assertThat(allowedBuild.output).contains(":app:transformDemoReleaseClassesWithAsm")
+  }
+
+  @Test
+  fun `skips both instrumentation visitors when both extensions ignore a build type`() {
+    applyRuntimeOptimizationIgnores(
+      ignoredBuildTypes = setOf("release"),
+      tracingInstrumentation = true,
+    )
+
+    val ignoredBuild = runner.appendArguments(":app:assembleFullRelease", "--dry-run").build()
+
+    assertThat(ignoredBuild.output).doesNotContain(":app:transformFullReleaseClassesWithAsm")
+    assertThat(ignoredBuild.output).contains(":app:uploadSentryProguardMappingsFullRelease")
+
+    val allowedBuild = runner.appendArguments(":app:assembleFullDebug", "--dry-run").build()
+
+    assertThat(allowedBuild.output).contains(":app:transformFullDebugClassesWithAsm")
+  }
+
   private fun applyIgnores(
     ignoredVariants: Set<String> = setOf(),
     ignoredBuildTypes: Set<String> = setOf(),
@@ -107,4 +209,64 @@ class SentryPluginVariantTest :
         .trimIndent()
     )
   }
+
+  private fun applyTracingIgnores(
+    ignoredVariants: Set<String> = emptySet(),
+    ignoredBuildTypes: Set<String> = emptySet(),
+    ignoredFlavors: Set<String> = emptySet(),
+  ) {
+    val variants = ignoredVariants.joinToString(",") { "\"$it\"" }
+    val buildTypes = ignoredBuildTypes.joinToString(",") { "\"$it\"" }
+    val flavors = ignoredFlavors.joinToString(",") { "\"$it\"" }
+    appBuildFile.appendText(
+      // language=Groovy
+      """
+                sentry {
+                  autoUploadProguardMapping = false
+                  runtimeOptimizations {
+                    enabled = false
+                  }
+                  tracingInstrumentation {
+                    enabled = true
+                    ignoredVariants = [$variants]
+                    ignoredBuildTypes = [$buildTypes]
+                    ignoredFlavors = [$flavors]
+                  }
+                }
+            """
+        .trimIndent()
+    )
+  }
+
+  private fun applyRuntimeOptimizationIgnores(
+    ignoredVariants: Set<String> = emptySet(),
+    ignoredBuildTypes: Set<String> = emptySet(),
+    ignoredFlavors: Set<String> = emptySet(),
+    tracingInstrumentation: Boolean = false,
+  ) {
+    val variants = ignoredVariants.joinToString(",") { "\"$it\"" }
+    val buildTypes = ignoredBuildTypes.joinToString(",") { "\"$it\"" }
+    val flavors = ignoredFlavors.joinToString(",") { "\"$it\"" }
+    appBuildFile.appendText(
+      // language=Groovy
+      """
+                sentry {
+                  autoUploadProguardMapping = false
+                  runtimeOptimizations {
+                    enabled = true
+                    ignoredVariants = [$variants]
+                    ignoredBuildTypes = [$buildTypes]
+                    ignoredFlavors = [$flavors]
+                  }
+                  tracingInstrumentation {
+                    enabled = $tracingInstrumentation
+                    ignoredVariants = [$variants]
+                    ignoredBuildTypes = [$buildTypes]
+                    ignoredFlavors = [$flavors]
+                  }
+                }
+            """
+        .trimIndent()
+    )
+  }
 }